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**HOW MIGHT YOU DEFY IMAGINATION?**

You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.

**Postdoctoral Fellow – Oncology Research**

**Live**

**What you will do**

Let’s do this. Let’s change the world. During this program, you will be provided with an enriching environment to inspire innovation that will contribute to the development of human therapeutics

The labs of Dr. Deepali Sawant and Dr. Matthew Chun in the Oncology Department at Amgen are seeking a highly motivated postdoctoral fellow with expertise in immuno-oncology to perform cutting-edge research designed to characterize the molecular mechanisms underlying T cell engager (TCE) activity for treatment of solid tumors. The candidate will design and perform experiments with the aim of understanding the impact of TCE target engagement on T cell fate and function. To address these questions, the postdoctoral fellow will use techniques such as single-cell sequencing, epigenomics, and metabolomics to profile T cell transcriptional and metabolic fate following TCE treatment, following up with in vitro and in vivo functional assays. Example topics of interest include characterizing the impact of cytokines and co-stimulation on T cell fitness and exhaustion in response to TCE engagement (see Belmontes, B., et al. Sci Transl Med. 2021. 13(608):eabd1524 for additional background).

During their tenure, the postdoctoral fellow will be encouraged and expected to develop an independent line of research based on initial studies and to present at scientific conferences and publish in leading journals. The chosen candidate will also have opportunities to interact with other postdoctoral fellows, scientists, and drug discovery teams throughout the Amgen community. The candidate will receive co-mentorship from two senior members of the Oncology Department and will have access to state-of-the-art technologies and resources including advanced Next Gen “omics” capabilities, human genetics, and in vitro and in vivo models.

The postdoctoral position is for 3 years with the option to extend for an additional year.

**Win**

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The dedicated individual we seek is a scientist with these qualifications:

**Basic Qualifications:**

+ Ph. D. at the time of appointment

**Preferred Qualifications:**

+ Ph. D. in Immunology or Cancer Biology with experience in immuno-oncology & T cell biology preferred

+ Demonstrated track record of independent critical thinking and scientific achievement in research, exemplified by first author publications in high-quality journals and presentations at external meetings and conferences

+ Expertise with current molecular, cell biology, and immunology laboratory techniques such as multi-color flow cytometry, isolation and culture of primary and established cell types, PCR/Western/ELISA/MSD

+ Prior experience with in vivo mouse models, tumor implantation and basic dosing techniques preferred

+ A minimum of basic bioinformatic skills with a desire to learn more.

+ Computer literacy, especially proficiency with FlowJo, GraphPad Prism, and Microsoft Word, Excel, and PowerPoint

+ Knowledgeable, highly motivated, creative, and collaborative with strong verbal and written communication skills

**Thrive**

**What you can expect of us**

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

The annual salary range for this opportunity in the U.S. is $81,522 – $90,586.

In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

+ Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

+ A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

+ Stock-based long-term incentives

+ Award-winning time-off plans and bi-annual company-wide shutdowns

+ Flexible work models, including remote work arrangements, where possible

You may visit the Post Doctoral Fellows Career Page (http://https/careers.amgen.com/opportunities/post-doctoral-fellowships/) for more information and opportunities.

**Apply now**

**for a career that defies imagination**

Objects in your future are closer than they appear. Join us.

**careers.amgen.com**

Join Us

If you’re seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you’ll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

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