Description
**ROLE SUMMARY**
An exciting opportunity is available for a Scientist to join the PK LCMS group in Pfizer Andover’s Pharmacokinetics Dynamics and Metabolism (PDM) department to support LCMS bioanalysis of novel biotherapeutics including ADCs. Your key responsibilities include PK LCMS assay development and qualification, sample analysis from PK/TK studies, data processing and reporting, ensuring optimal LCMS instrument operation and maintenance. In this laboratory-based role you will employ various sample preparation strategies with focus on analyte enrichment/extraction from blood or tissue using protein or peptide immunoaffinity or other methods in conjunction with LCMS-based peptide detection. In addition, your responsibilities will include technology development and adherence to scientific and ethical standards, including electronic documentation and peer review. With your contemporary skills, you will contribute to the transformation of our workflows using AI-enhanced computational tools. As an independent scientist, who pays attention to detail and is eager to learn, you will collaborate within multidisciplinary teams and your data will make a crucial contribution to the discovery and development of novel biotherapeutic candidate molecules.
**ROLE RESPONSIBILITIES**
+ Responsible for the development, qualification and implementation of PK/PD assays using mass spectrometry in support of discovery and preclinical projects.
+ Works with group leads or other discovery and regulated bioanalytical team members and project team members to accomplish goals.
+ Participates in technology development and implementation by exploring new workflows, including automation, high throughput sample preparation and instrumentation in protein quantitation, to expand the group’s PK LCMS bioanalytical capabilities.
+ Participate in all phases of mass spectrometry laboratory operations including technology evaluations, the development of sample preparation and separation methods, data analysis, interpretation, reporting and follow up discussions with the project teams on utilizing the data in appropriate decision making.
+ Ensure all tasks and responsibilities are carried out according to scientific and ethical standards e.g. responsible for electronic notebook record keeping; QC and peer review of data and reports.
**QUALIFICATIONS**
**Must Have**
+ MS with have 4 to 6 years of relevant work experience, ideally mostly in industry (or BS/BA with 6 to 8 years of experience).
+ Expertise in development, characterization, and implementation of bioanalytical LCMS assays.
+ Experience in the operation and troubleshooting of LCMS instrumentation and associated operating/data analysis software including Skyline, Analyst, Sciex OS and Xcalibur.
+ Hands-on experience of biological sample preparation procedures for quantitative LCMS assays on biotherapeutics.
+ Knowledge of writing scripts to set up methods for automated liquid handler system
+ Knowledge of protein biochemistry of therapeutic antibodies, fusion proteins or ADCs.
**Nice-to-Have**
+ Expertise in quantitative tissue bioanalysis and extraction methodologies of large molecules.
+ Expertise in biological sample preparation techniques (immunoaffinity, tryptic digestion, tissue processing, conjugation, etc) of various biofluids.
+ Ability to work both independently and as part of a team, multitasking multiple programs.
+ Experience working in a regulated bioanalytical laboratory and knowledge of GLP’s is a plus.
+ Knowledge to implement AI tools to facilitate data visualization, bioanalytical assay development and optimization.
**NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS**
+ Lab based position requiring performing all typical laboratory related activities
+ Based in Andover
+ Occasional travel to Cambridge (Kendal Square) is required, depending on project needs
Work Location Assignment: On Premise
The annual base salary for this position ranges from $79,400.00 to $128,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
**Sunshine Act**
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
**EEO & Employment Eligibility**
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development
