Description

**WE ARE LOOKING FOR YOU**

Amgen Research (Munich) GmbH, one of Amgen’s state-of-the-art research hubs located in the south of Munich and home to approximately 170 employees, is currently seeking a highly motivated and qualified:

**Scientist / Senior Scientist (m/f/d)**

**Department: TSRS Nonclinical**

**Employment Type: Full-time, Fixed-term (3 years)**

**Start Date: As soon as possible**

We are seeking a highly skilled and motivated scientist to join our Portfolio, Pharmacology and Data Sciences Department at the Scientist/Sr Scientist level. The successful candidate will conduct advanced research in the areas of 3D cell culture and organ-on-chip systems, creating in vitro cellular models and relevant assays for the safety evaluation of new drug candidates.

**_This role can be positioned either on_** **_GCF Level 5-1 (Scientist)_** **_or_** **_5-2 (Senior Scientist)_** **_, depending on professional qualification_**

**_and experience._**

**TASKS:**

**Develop and implement** **new in vitro and ex vivo methods to support the development of** **New Approach Methodologies** **(NAMs) for nonclinical safety assessment.**

**Application of 3D cell culture models (organoids** **/** **organs-on-a-chip technologies)** **that replicate various human organs (e.g., lung, lymph node, liver, pancreas, blood vessels, skin) and their associated diseases (e.g., cancer, autoimmunity) for drug screening and safety assessment applications.**

**Characterization** **of 3D cell culture models using fluorescence microscopy, flow cytometry, or gene/protein expression.**

**Qualifying 3D cell culture** **models for a particular use by quantifying their ability to predict known clinical outcomes.**

**Conducting** **relevant cellular/molecule** **functional in vitro assays** **on the efficacy and toxicity of potential drug candidates (e.g., antibodies) utilizing plate-based immunoassays, FACS and cell-based imaging with minimal supervision.**

**Develop hypotheses and design experimental plans** **to propose creative and novel solutions, execute experiments, and analyze and interpret results.**

**Collaborate cross-functionally** **with various scientific teams, sharing ideas and proposing solutions for scientific and clinical challenges during regular group meetings and internal seminars.**

**Engage** **in appropriate training of lab personnel and lab maintenance, including equipment maintenance and ordering supplies.**

**Manage projects independently** **and contribute to their intellectual advancement.**

**Stay updated on current literature** **in organoids and organs-on-a-chip technology and related fields.**

**Qualifications and requirements:**

**Master’s Degree** **with 3+ years of experience or** **PhD degree** **in cell biology, immunology, biochemistry, or related fields.**

**In-depth knowledge** **and** **hands-on experience** **with cell cultures such as immortalized cells, particularly in 3D cell culture models and organs-on-a-chip technologies, including design, characterization, and validation as well as in cell-based assays, molecular biology, immunology, and biochemical techniques.**

**Skilled in biomarker detection** **techniques, including ELISA and ELISPOT.**

**Strong analytical and problem-solving skills** **.**

**Excellent verbal and written communication skills** **in English and German, with a strong willingness to collaborate in a global environment.**

**Preferably direct experience developing organoids or organs-on-a-chip model within academia or a model development company.**

**WHAT WE OFFER TO YOU**

**Flexible working hours**

**38-hour work week**

**30 days of annual vacation**

**Additional leave for special occasions (e.g., wedding, relocation, etc.)**

**Access to** **EGYM Wellpass** **for fitness and wellness**

**Busuu** **language learning app subscription**

**Meal subsidy of €1.50 per day**